Jessica J. Walsh

This paper introduces engineered mouse models to study the effects of psychedelic drugs by examining HTR2A receptor expression and function.

The paper uses cryo-EM to analyze endogenous mGluR2-containing receptor assemblies in mouse brain, revealing distinct structural states and complexes not previously observed in recombinant systems.

The paper investigates whether mGluR2 and 5-HT2A receptors physically interact in vitro or in vivo and finds no evidence for direct interaction or oligomerization.

This study identifies the somatosensory cortex as a sex-specific regulator of high-fat diet intake through brain-wide activity mapping and chemogenetic manipulation in mice.

This study investigates the differential roles of D1- and D2-MSNs in regulating hedonic feeding in male and female mice using optogenetics, chemogenetics, and fiber photometry.

This study identifies distinct neural mechanisms for MDMA's prosocial effects and rewarding properties in mice, showing serotonin transporter and dopaminergic signaling play separate roles.