Author

D. Dewran Koçak

University of North Carolina at Chapel HillORCID 0000-0001-6934-6964Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Bryan L. RothiD· 2 shared Grégory ScherreriD· 2 shared Jessica J. WalshiD· 2 shared Karen Lu Huang· 2 shared Kunjie Hua· 2 shared Pierre LlorachiD· 2 shared Yi-Ting ChiuiD· 2 shared Alejandro BarreraiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Bryan L. RothORCID

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3 papers

Recent·Most cited

A suite of engineered mice for interrogating psychedelic drug actions

Yi-Ting Chiu, Ariel Y. Deutch, Wei Wang, Gavin P. Schmitz, Karen Lu Huang, D. Dewran Koçak, Pierre Llorach, Kasey Bowyer, Bei Liu, Noah Sciaky, Kunjie Hua, Chongguang Chen, S. Mott, Jesse K. Niehaus, Jeffrey F. DiBerto, , Bryan L. Roth

This paper introduces engineered mouse models to study the effects of psychedelic drugs by examining HTR2A receptor expression and function.

Nature Neuroscience · Aug 6, 2026Peer-reviewedNeuroscience

Cryo-EM Structures of Brain-Derived G Protein-Coupled Receptors

Nicholas A. Wright, Yi-Ting Chiu, Kensuke Sakamoto, D. Dewran Koçak, Pierre Llorach, Blake A. Fordyce, Kunjie Hua, Karen Lu Huang, Grégory Scherrer, Scott P. Lyons, Steven C. Bremmer, Lee M. Graves, Jessica J. Walsh, Bryan L. Roth

The paper uses cryo-EM to analyze endogenous mGluR2-containing receptor assemblies in mouse brain, revealing distinct structural states and complexes not previously observed in recombinant systems.

bioRxiv · Jul 9, 2026 · PreprintNeuroscience

SMARCA2 is an essential and potent cofactor for a specific subset of the glucocorticoid response in A549 cells

Schuyler M. Melore, D. Dewran Koçak, Keith Siklenka, Graham D. Johnson, Courtney A. Williams, Luke C. Bartelt, Angela G. Jones, Alejandro Barrera, Revathy Venukuttan, Charles A. Gersbach, Timothy E. Reddy

The paper identifies SMARCA2 as a critical cofactor for a subset of glucocorticoid response genes in A549 cells through a CRISPR screen and functional analysis.

bioRxiv · Nov 13, 2025 · PreprintGenomics