Yi-Ting Chiu

This paper introduces engineered mouse models to study the effects of psychedelic drugs by examining HTR2A receptor expression and function.

The paper uses cryo-EM to analyze endogenous mGluR2-containing receptor assemblies in mouse brain, revealing distinct structural states and complexes not previously observed in recombinant systems.

The paper investigates whether mGluR2 and 5-HT2A receptors physically interact in vitro or in vivo and finds no evidence for direct interaction or oligomerization.

This study shows psilocin excites 5-HT2A Layer 5 Pyramidal Neurons in the mouse PFC via a Gq-mediated mechanism, increasing firing without affecting synaptic transmission.

This study investigates how LSD affects behavior in mice lacking beta-arrestin 1 or 2, revealing distinct roles for these proteins in mediating LSD's effects.