Author

Jun Ishihara

Imperial College LondonORCID 0000-0002-9083-9859Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Charanjit SinghiD· 2 shared Chuyi WangiD· 2 shared John K. LeeiD· 2 shared Koichi SasakiiD· 2 shared Laurine NoblecourtiD· 2 shared Po-Chuan ChiuiD· 2 shared Pooja KauriD· 2 shared Saul J. PricemaniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBioengineering

Charanjit SinghORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Collagen targeting IL-12 combined with Doxorubicin enhances the anti-tumor effect against osteosarcoma

Takumi Matsuo, Laurine Noblecourt, Pooja Kaur, Chuyi Wang, Po-Chuan Chiu, Koichi Sasaki, Takanatsu Hosokawa, Charanjit Singh, Adrian Lärkeryd, Tomonori Ueno, Kazunori Mizuno, Anguraj Sadanandam, Paul H. Huang, Jun Ishihara

This study combines collagen-targeted IL-12 with doxorubicin to improve anti-tumor effects in osteosarcoma by enhancing tumor accumulation and immune activation.

Journal of Controlled Release · Sep 26, 2026Peer-reviewedBioengineering

Albumin-fused interleukin-10 prevents experimental autoimmune encephalomyelitis by promoting immunoregulation in the secondary lymphoid organs

Erica Budina, Joseph W. Reda, Kirsten C. Refvik, Julia Luehr, Brendan Thomas Kane Berg, Hye Rin Chun, Taryn N. Beckman, Ani Solanki, Mindy Nguyen, Sofia N. Reda, Colleen Foley, Ivan Vuong, Abigail L. Lauterbach, Kevin Hultgren, Suzana Gomes, , Jeffrey A. Hubbell

This study shows that albumin-fused IL-10 reduces experimental autoimmune encephalomyelitis by enhancing immunoregulation in secondary lymphoid organs.

bioRxiv · Sep 14, 2026 · PreprintImmunology

Collagen-binding IL-12 expressing STEAP1 CAR-T cells reduce toxicity and eradicate mouse prostate cancer in combination with checkpoint inhibitors

Koichi Sasaki, Vipul Bhatia, Yuta Asano, Jakob Bakhtiari, Pooja Kaur, Chuyi Wang, Takumi Matsuo, Olivier Dubois, Po-Chuan Chiu, Donny Gun, Charanjit Singh, Ioanna Panagi, Laurine Noblecourt, Maria Nikolaidi, Truman Chong, , Jun Ishihara

Nature Biomedical Engineering · Oct 23, 2025Peer-reviewedBioengineering

Solid tumor CAR T cells engineered with fusion proteins targeting PDL1 for localized IL-12 delivery

John Paul Murad, Lea Christian, Reginaldo Cruz Alves Rosa, Yuwei Ren, Eric Lee, Lupita S. Lopez, Anthony J. Park, Jason Yang, Candi Trac, Lauren N. Adkins, Wen‐Chung Chang, Catalina Martinez, Carl H. June, Stephen J. Forman, Jun Ishihara, , Saul J. Priceman

This study engineers CAR T cells with PDL1-IL12 fusion proteins to enhance anti-tumor responses in solid tumors by improving T cell function and reducing systemic inflammation.

bioRxiv · Apr 4, 2025 · PreprintBioengineering