Author

Alex Dyson

Manchester Academic Health Science CentreORCID 0000-0001-8498-1691Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. Gareth EvansiD· 2 shared Richard BainesiD· 2 shared Shruti GargiD· 2 shared Megan Ryan· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersNeuroscience

D. Gareth EvansORCID

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2 papers

Recent·Most cited

NeuroscienceeNeuroPeer-reviewedApr 26, 2023

A targeted, low-throughput compound screen in a Drosophila model of Neurofibromatosis Type 1 identifies simvastatin and BMS-204352 as potential therapies for autism spectrum disorder (ASD).

Alex Dyson, Megan Ryan, Shruti Garg…·Richard Baines

This study identifies simvastatin and BMS-204352 as potential ASD therapies in a Drosophila Nf1 model by reducing tactile hypersensitivity and synaptic transmission defects.

7 citations

Drosophilaexperimental assay

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NeurosciencebioRxivPreprintMar 4, 2022

Loss of NF1 causes tactile hypersensitivity and impaired synaptic transmission in a Drosophila model of autism spectrum disorder

Alex Dyson, Shruti Garg, D. Gareth Evans, Richard Baines

This study shows that loss of NF1 in Drosophila causes tactile hypersensitivity and synaptic transmission deficits, similar to ASD features, and these effects are rescued by knocking down Ras proteins.

DOI 10.1101/2022.03.04.482984

Drosophilaexperimental assay

𝕏 PostBluesky