Adı́lson Guilherme

This study shows that adipocyte Nrip1 deficiency in obese mice reduces hepatic steatosis and insulin resistance by promoting M2-like macrophages that secrete IL-1rn.

This study identifies PTHrP as a driver of pancreatic cancer cachexia by suppressing adipose de novo lipogenesis, showing that blocking PTHrP-PTH1R signaling reduces wasting in mouse models.

This study identifies Ncoa4 as a regulator of PPARγ activity and thermogenesis in brown adipose tissue through genetic and functional analyses.

This study identifies de novo lipogenesis as a critical source of fatty acids for autophagosome membrane dynamics in adipocytes, showing that Fasn deficiency impairs autophagy and p62 degradation.

The paper identifies proteomic and metabolic changes in brown fat tissue in response to cold exposure, highlighting increased acetylation and lipid synthesis.