Mikael Sigvardsson

The paper shows GATA transcription factors modulate Wnt/β-catenin signaling to control cell identity in the intestinal epithelium by repressing secretory lineage genes in stem cells.

The paper identifies diverse human antibody-secreting cell subsets using multi-omic methods and shows their distinct functional and spatial characteristics.

This study shows how multiple myeloma and its treatment alter the bone marrow niche, impairing immune reconstitution and vaccine responses, with mRNA vaccines showing better efficacy than influenza vaccines.

The paper creates a cell-type-specific IFN response atlas to distinguish IFN-I and IFN-II activities in human immune cells across diseases.

This study uses multi-omic profiling to analyze immune cell dynamics in healthy adults over time, finding age-related transcriptional changes in T cells and impaired memory B cell responses in older adults.

The paper annotates distal cis-regulatory elements using chromatin interactions and shows their dynamic role in lymphocyte development, particularly in B-cell differentiation.