Linlin Li

Stochastic Modeling of BMP Heterodimer-Receptor Interactions Shows Emergence of Low-Pass Filtering Behavior

The paper develops a stochastic model of BMP receptor interactions to show the heterodimer-heterotetramer complex functions as a low-pass filter in zebrafish dorsoventral axis formation.

A feed-forward loop between niche adenosine and Gzmk⁺ CD8 T cells propagates systemic inflammaging

This study identifies an adenosine-Gzmk axis that drives T cell aging and systemic inflammaging, showing that targeting it can reverse aging phenotypes and extend lifespan in mice.

Reactive Oxygen Species Counteract Wound Contraction and Promote Wound Healing

This study shows ROS inhibit myosin phosphorylation to counteract wound contraction, delay closure, and impair regrowth, while chronic ROS depletion alters tissue stiffness and impairs healing.

Digital Cousins: Simultaneous Optimization of One Model for BMP Signaling in Distant Relatives Reveals Essential Core

The paper develops a core mathematical model of BMP signaling that can replicate gradient dynamics in both Drosophila and zebrafish with minimal parameter changes.

Optimal Performance Objectives in the Highly Conserved Bone Morphogenetic Protein Signaling Pathway

The paper examines how the BMP-Smad pathway balances trade-offs among response speed, noise amplification, and sensitivity to receptor input by tuning non-conserved parameters.

Quantitative imaging in whole-mount zebrafish embryos traces morphogen gradient maintenance and noise propagation in BMP signaling

The paper quantifies BMP signaling gradients in zebrafish embryos and shows how noise and Sizzled maintain the gradient during DV patterning.

WaveletSEG: Automatic wavelet-based 3D nuclei segmentation and analysis for multicellular embryo quantification

WaveletSEG provides a robust, automatic 3D nuclei segmentation method for multicellular embryo analysis without preprocessing, achieving high accuracy in noisy data.

Evaluation of BMP-mediated patterning in a 3D mathematical model of the zebrafish blastula embryo

The paper develops a 3D PDE model to simulate BMP signaling during zebrafish blastula development and evaluates its sensitivity to biophysical parameters.