Sascha R.A. Alles

This study examines gabapentin's effects on human dorsal root ganglia neurons, showing donor-specific electrophysiological responses and transcriptomic changes that are modulated by the drug.

The paper examines circRNA expression in human dorsal root ganglia (hDRG) under opioid exposure and identifies differentially expressed circRNAs and their potential regulatory roles in pain pathways.

This study investigates neuroimmune mechanisms in a mouse model of chronic back pain, finding increased macrophage activity and neuronal hyperexcitability in dorsal root ganglia.

This study compares electrophysiological properties of human dorsal root ganglia and hiPSC-derived sensory neurons from male and female donors, identifying significant differences and correlations.

This study investigates how BDNF affects neuronal activity in the spinal superficial dorsal horn, showing it both suppresses some neurons and activates a subpopulation of silent neurons.

This study identifies opioid-dependent inhibition of neurotransmitter release as the primary mechanism of analgesia in NaV1.7 null mutants in mice and humans.

This study shows that Nav1.7 from sensory neurons affects dorsal horn neuron excitability, with functional effects not predicted by mRNA levels.