Filipe Nascimento

Neuronal targeted AAV Micro-Dystrophin restores neurobehavioural co-morbidities, grip strength and motor coordination in mdx52 mouse model of Duchenne Muscular Dystrophy

This study evaluates neuronal-targeted AAV micro-dystrophin therapy in mdx52 mice, showing IV delivery improves neurobehavioural, motor, and neuromuscular deficits more effectively than ICV delivery.

High-frequency common inputs entrain motoneuron subpopulations differently

The paper shows that high-frequency common inputs affect motoneuron subpopulations differently, revealing frequency-dependent synchronization masked in whole-pool analyses.

In vivo motor unit decoding and in vitro cellular characterisation of spinal circuits for urination in adult mice

The paper characterizes the cellular and circuit properties of perineal motor control in adult mice, revealing distinct biophysical features and motor unit recruitment patterns during urination.

Intrinsic spinal cord circuits compare sensory inputs and efference copies to correct for perturbations to ongoing movement

This study identifies dI3 neurons in the spinal cord that compare efference copies and sensory feedback to enable rapid movement corrections.

Personalized mapping of inhibitory spinal cord circuits in vivo via non-invasive neural decoding and in silico modelling

This study uses high-density surface EMG and in silico modelling to reveal subject-specific inhibitory spinal microcircuit properties and control strategies.

Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration

The paper investigates how spinal microcircuits adapt in a mouse model of motoneuron degeneration, finding specific multiphasic homeostatic compensations that preserve force output.

On the origin of F-wave: involvement of central synaptic mechanisms

This study investigates the origin of F-waves in mice, showing they are mediated by spinal microcircuits via glutamatergic synapses from motor axon collaterals.

In vitro longitudinal lumbar spinal cord preparations to study sensory and recurrent motor microcircuits of juvenile mice

This paper describes two in vitro longitudinal lumbar spinal cord preparations from juvenile mice to study sensory and motor microcircuits using whole-cell patch-clamp electrophysiology.

Pathophysiology of Dyt1 dystonia is mediated by spinal cord dysfunction

This study shows that spinal cord dysfunction contributes to DYT1 dystonia by creating mouse models with dystonia-like symptoms.

Sensory neuron-derived Nav1.7 contributes to dorsal horn neuron excitability

This study shows that Nav1.7 from sensory neurons affects dorsal horn neuron excitability, with functional effects not predicted by mRNA levels.