John N. Wood

Suzetrigine-evoked analgesia is potentiated by Nav1.7 null-related opioid mechanisms.

The paper investigates how Nav1.7 loss enhances opioid signaling and analgesia, showing that suzetrigine-evoked analgesia is potentiated by RGS antagonists and low-dose morphine in inflammatory pain models.

Analgesic targets identified in mouse sensory neuron somata and terminal pain translatomes

The paper identifies analgesic targets in mouse sensory neurons by analyzing translatomes in somata and terminals under different pain conditions.

Novel therapies for cancer-induced bone pain

This study evaluates three potential treatments for cancer-induced bone pain in mice, finding that dual inhibition of NGF and TNF significantly reduces pain-related behaviors.

Two distinct mechanisms for Nav1.7 null analgesia

The paper compares genetic and pharmacological loss-of-function mechanisms of Nav1.7 analgesia, highlighting distinct opioid-dependent and -independent pathways in embryonic and adult stages.

Transcriptomic profiling reveals a pro-nociceptive role for Angiotensin II in inflammatory bowel disease

This study identifies Angiotensin II as a pro-nociceptive mediator in IBD by showing increased Agt expression and AT1 receptor activation in colonic neurons.

Chemogenetic silencing of NaV1.8 positive sensory neurons reverses chronic neuropathic and bone cancer pain in FLEx PSAM4-GlyR mice

Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia

This study shows that neutrophils infiltrate sensory ganglia and contribute to chronic widespread pain in fibromyalgia by conferring mechanical hypersensitivity in mice.

Molecular basis of FAAH-OUT-associated human pain insensitivity

The paper identifies how the FAAH-OUT lncRNA regulates FAAH expression through DNA methylation and enhancer activity, linking it to pain insensitivity.

Pregabalin silences oxaliplatin-activated sensory neurons to relieve cold allodynia

This study shows pregabalin reduces cold allodynia caused by oxaliplatin by silencing specific sensory neurons through the 2{delta}-1 subunit of voltage-gated calcium channels.

Transcriptomic and proteomic profiling of NaV1.8-expressing mouse nociceptors

The paper profiles transcriptomic and proteomic data from NaV1.8-expressing mouse nociceptors, identifying 353 transcripts and 78 proteins, and finds moderate correlation between proteome and transcriptome datasets.

Sensitization of cutaneous primary afferents in bone cancer revealed by in vivo calcium imaging

The paper investigates changes in bone-innervating afferents in cancer-induced bone pain using calcium imaging and retrograde labeling, finding altered excitability in cutaneous afferents but not bone marrow afferents.

The mechanism of analgesia in Nav1.7 null mutants

This study identifies opioid-dependent inhibition of neurotransmitter release as the primary mechanism of analgesia in NaV1.7 null mutants in mice and humans.

Silent cold-sensing neurons drive cold allodynia in neuropathic pain states

The paper identifies silent cold-sensing neurons that become active in neuropathic pain and contribute to cold allodynia through peripheral sensitization.

Sensory neuron-derived Nav1.7 contributes to dorsal horn neuron excitability

This study shows that Nav1.7 from sensory neurons affects dorsal horn neuron excitability, with functional effects not predicted by mRNA levels.

CRISPR interference at the FAAH-OUT genomic region reduces FAAH expression

The paper shows that CRISPR interference at the FAAH-OUT region reduces FAAH expression, supporting its role in regulating FAAH and suggesting therapeutic potential.

PGP-UK: a research and citizen science hybrid project in support of personalized medicine

PGP-UK explores citizen science in genomics by recruiting participants, sharing data, and developing tools to advance personalized medicine.

Analgesia linked to Nav1.7 loss of function requires mu and delta opioid receptors

The paper shows that Nav1.7 loss of function analgesia requires both mu and delta opioid receptors, and enkephalin upregulation alone is insufficient for analgesia.

Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene targeted mice

The paper identifies 267 NaV1.7-associated proteins in mice using epitope-tagged gene targeting and mass spectrometry, including novel interactors validated by co-immunoprecipitation and functional assays.

Brain-derived neurotrophic factor derived from peripheral sensory neurons plays a critical role in pain chronification

This study shows that BDNF from peripheral sensory neurons is critical for transitioning acute to chronic pain.

Regulation of somatosensory mechanotransduction by Annexin A6

This study identifies Annexin A6 as a modulator of somatosensory mechanotransduction by affecting mechanically-activated currents in sensory neurons.

Intracellular Sodium Regulates Opioid Signalling in Peripheral Sensory Neurons

The paper shows that increased intracellular sodium inhibits fentanyl's effect on Nav1.8 currents in sensory neurons.