Author

Jacob Beiriger

Thomas Jefferson UniversityORCID 0000-0001-8552-787XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Shao· 2 shared Fatemeh NiaziorimiiD· 2 shared Ibtesam RajpariD· 2 shared Koen van de WeteringiD· 2 shared Celina NgiD· 1 shared Deana Mancuso· 1 shared Nicholas Yancy· 1 shared Petri A. TurhaneniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPharmacology & Toxicology

C. Shao

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintJul 16, 2026

Phosphocitrate Is Superior to Pyrophosphate in Preventing Soft Connective Tissue Calcification in a Mouse Model of Pseudoxanthoma Elasticum

Ibtesam Rajpar, C. Shao, Celina Ng…·Koen van de Wetering

This study shows phosphocitrate is more effective than pyrophosphate in reducing calcification in PXE mice, with better oral bioavailability and fewer side effects.

DOI 10.64898/2026.07.10.737791

mouseexperimental assay

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PathologybioRxivPreprintJul 16, 2025

High-dose oral pyrophosphate inhibits connective tissue calcification in Abcc6 null mice but affects bone structure

Ibtesam Rajpar, Nicholas Yancy, Jacob Beiriger…·Koen van de Wetering

This study shows that only very high oral doses of pyrophosphate inhibit ectopic calcification in Abcc6-/- mice, but these doses harm bone structure and are impractical for human use.

2 citations

mouseexperimental assay

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