Eric Martínez

The paper reports a large-scale quantitative interactome of human PDZ domains and bacterial PDZ-binding motifs, showing bacteria tailor effector sequences to bind with similar or higher affinity than human PBMs to hijack host functions.

This study shows that SARS-CoV-2 nucleocapsid protein interacts with viral RNA and ERGIC lipids to drive viral core assembly through lipid clustering and RNP stabilization.

This study identifies the Coxiella effector Vice as a protein that manipulates host cell lipid composition and cellular pathways to form the Coxiella-containing vacuole.