Donita C. Brady

Mitochondrial copper stabilizes lipoylated TCA cycle proteins to sustain metabolism and proliferation

This study shows mitochondrial copper stabilizes lipoylated TCA cycle proteins, maintaining metabolism and proliferation by supporting lipoylation and TCA cycle function.

Reduction in Hepatic Phosphatidylcholine Biosynthesis Promotes MASH Through Copper Deficiency

This study shows that reduced hepatic phosphatidylcholine biosynthesis leads to copper deficiency, which promotes MASH through disrupted copper distribution and fibrogenesis.

MAPK Pathway Inhibition Reshapes Kinase Chemical Probe Reactivity Reflecting Cellular Activation States

This study uses ABPP to show how MAPK pathway inhibitors alter kinase residue reactivity, reflecting conformational changes and resistance mechanisms in melanoma cells.

A selective S-acyltransferase inhibitor suppresses tumor growth

The paper identifies an inhibitor of S-acyltransferase ZDHHC20 that suppresses Kras mutant lung tumor growth and improves survival.