Jordi C. J. Hintzen

This paper demonstrates the use of ubiquitin-derived diglycine remnants as chemical handles for chemoenzymatic proteomics, enabling antibody-independent analysis of protein ubiquitination.

The paper identifies and optimizes quinazolinone and phthalazinone inhibitors targeting the HDAC6 ZnF-UBD/ubiquitin interaction, using computational and experimental methods to improve their physicochemical properties and predict binding affinity.

This study shows mitochondrial copper stabilizes lipoylated TCA cycle proteins, maintaining metabolism and proliferation by supporting lipoylation and TCA cycle function.

The paper shows that extended O-glycans are present on intranuclear proteins and demonstrate their role in RNA processing through specific examples.

This study evaluates the selectivity of the peptidomimetic inhibitor BzLPRDSar against Gram-positive bacteria, showing potent inhibition of biofilm formation in multidrug-resistant Staphylococcus species.

The paper examines rRNA transcription and abundance in normal and leukemic hematopoiesis, finding cell-type-specific variations and functional roles in myeloid differentiation.