Heikki Tanila

This paper generates a Cln8 p.R24G mouse model that phenocopies major clinical features of Northern epilepsy, including seizures and neurodegeneration.

The paper describes a FINCA mouse model with mild hyperactivity and altered immune response, identifying Rho GTPase signaling as a key pathway affected by the p.Asp148Tyr variant in NHLRC2.

This study uses fMRI to show that whisker stimulation in awake rats activates multiple sensory systems, with distinct responses in core and non-core brain regions, and that anesthesia obscures high-order processing.

This study shows that the PLCgamma2-P522R variant reduces beta-amyloid pathology and enhances microglial function in AD models, suggesting an anti-ageing mechanism.

This paper introduces MB-SWIFT fMRI to study whole-brain activity in head-fixed rats during spontaneous behavior, showing functional parcellation and behavior-related brain activity.

This study shows that a diabetic phenotype in mice and humans reduces microglial response to β-amyloid plaques, linking T2D and AD pathologies.

The paper shows that astrocytes from schizophrenia patients exhibit transcriptional and functional changes, including inflammation and synaptic pathway alterations, which are partially reversible with clozapine treatment.

This study investigates how theta and gamma oscillations in the rat hippocampus coordinate during a timing task, finding that their synchronization varies with task performance and error types.