Jari Koıstınaho

The paper examines proteasome composition and activity in human iPSC-derived cortical neurons from early-stage sporadic Alzheimer's disease patients, finding increased 20S proteasome assemblies and proteolytic activity.

This study identifies a schizophrenia-associated radial glia cell state that disrupts early human brain development through single-cell transcriptomic and epigenomic analyses of organoids.

This study shows SARS-CoV-2 infects hiPSC-derived neurons via endosomal-lysosomal pathway dependent on cathepsins, leading to HIF1alpha accumulation and phosphorylated tau, suggesting neurodegenerative effects.

This study shows that iPSC-derived neurons from FTD patients exhibit synaptic dysfunction, DNA damage, and C9-HRE-related pathologies, supporting synaptic dysfunction as a key factor in FTD.

This study shows that human iPSC-derived pericyte-like cells with the APP Swedish mutation overproduce beta-amyloid and exhibit CAA-like features in vitro.

This study shows that the PLCgamma2-P522R variant reduces beta-amyloid pathology and enhances microglial function in AD models, suggesting an anti-ageing mechanism.

This study shows that C9orf72 repeat expansion in iPSC-derived microglia from FTD patients leads to increased phagocytic activity and reduced autophagosomal-lysosomal vesicles.

This paper develops a patient-derived BBB model to screen copper bis(thiosemicarbazone) complexes for Alzheimer's disease treatment, identifying CuII(dtsm) as a promising candidate with improved BBB permeability and anti-inflammatory effects.

The paper shows that ciRS-7 and miR-7 regulate ischemia-induced neuronal death through glutamatergic signaling in mice.

The paper shows human astrocytes influence neuronal network burst frequency via NMDA receptors, with differences between human and rat astrocytes and effects in schizophrenia-related cells.

This study shows that kynurenic acid promotes microglia-mediated synaptic pruning in schizophrenia by reducing neuronal activity and linking genetic risk variants to KYNA production.

This study shows that activating PIEZO1 channels in microglia improves amyloid beta clearance in AD models by enhancing survival, phagocytosis, and lysosomal activity.

This study shows increased mitochondrial internalization and degradation by astrocytes in Alzheimer's disease, suggesting altered neuron-supporting functions and involvement of S100a4 and Ambra1.

The paper identifies molecular pathways and potential treatments for schizophrenia using stem cell-derived neurons and pharmacological associations.

This study investigates the role of meningeal lymphatic vessels in modulating the neuro-immune response after traumatic brain injury in mice, finding reduced CD4+ T cell infiltration in their absence.

This study shows that incorporating microglial progenitors into human brain organoids supports neuronal maturation and synaptic activity.

The paper shows that astrocytes from schizophrenia patients exhibit transcriptional and functional changes, including inflammation and synaptic pathway alterations, which are partially reversible with clozapine treatment.