Miguel A. Gutierrez‐Monreal

This paper constructs a spatial metabolomic atlas of exercise in mice, identifies Complex I as a key target for reducing tau pathology, and shows that enhancing its activity mimics exercise's protective effects.

The paper generates a nucleus-resolved transcriptomic atlas of skeletal muscle insulin resistance using single-nucleus transcriptomics and stable isotope-labeled clamps, identifying cell-specific molecular programs and targets.

This study investigates the effects of conditional dystrophin ablation in skeletal muscle and brain, revealing functional deficits and pathway dysregulation in both tissues.

This study develops a chronic TBI mouse model and finds that TBI leads to lifelong sleep/wake disturbances, circadian disruptions, and neuropathology.

This study shows that targeted brain-specific tauopathy in mice leads to skeletal muscle weakness and altered gene expression.

This study identifies age-dependent and tissue-specific changes in the circadian transcriptome of male mice, showing reduced rhythmic gene expression and increased variability in aged tissues.

The paper profiles transcriptional diversity across skeletal, smooth, and cardiac muscles in mice and rats, revealing extensive gene expression differences and disease associations.