Karyn Ann Esser

This study shows that FAM210A deficiency in hepatocytes causes juvenile mitochondrial dysfunction and steatosis, which resolves in adulthood through compensatory mechanisms.

This study identifies shared and sex-specific molecular responses to endurance training in skeletal muscle using multi-omics data from rats.

This study shows that housing mice in thermoneutrality alters tissue-specific circadian gene expression without changing core clock genes.

This paper constructs a spatial metabolomic atlas of exercise in mice, identifies Complex I as a key target for reducing tau pathology, and shows that enhancing its activity mimics exercise's protective effects.

This study identifies FBXL21 as a circadian E3 ligase that regulates proteostasis and stress response by targeting DNAJB6 and its client proteins, with implications for myopathies.

The paper identifies tissue-specific transcriptional regulatory programs in rats undergoing endurance exercise training by integrating chromatin accessibility, DNA methylation, and gene expression data.

The paper profiles multi-omic changes in abdominal subcutaneous adipose tissue after acute exercise in sedentary adults, identifying distinct molecular programs and candidate exerkines.

This study identifies sex-specific multi-omic responses to endurance exercise training in rat lungs, revealing differences in immune pathways and mitochondrial acetylation between males and females.

BayesCNet improves inference of cell type-specific regulatory networks by leveraging cell type hierarchy, outperforming existing methods, especially for rare cell types.

This paper introduces a Bayesian framework for detecting circadian rhythmicity biomarkers across the genome, showing improved false discovery rate control and performance in RNA-sequencing data.

This study identifies changes in the skeletal muscle nuclear proteome after acute exercise, revealing post-transcriptional effects on mRNA processing and splicing.

Correlation-based endocrine network analysis of MoTrPAC rat multi-tissue omics shows 8-week endurance training reshapes inter-organ secretory crosstalk, centering subcutaneous adipose, extracellular matrix factors, and Wnt regulators.

This study investigates the effects of conditional dystrophin ablation in skeletal muscle and brain, revealing functional deficits and pathway dysregulation in both tissues.

This study shows that cardiomyocyte Bmal1 is essential for sex-specific gene expression in the adult mouse heart, as its loss reduces sex differences in circadian transcriptomes.

CosinorTest is an R Shiny app for circadian and differential analysis of transcriptomic data using Cosinor models, offering tools for rhythmicity detection, differential pattern assessment, and visualization.

This study shows that targeted brain-specific tauopathy in mice leads to skeletal muscle weakness and altered gene expression.

This study identifies age-dependent and tissue-specific changes in the circadian transcriptome of male mice, showing reduced rhythmic gene expression and increased variability in aged tissues.

The paper develops linear mixed model methods to detect circadian rhythmicity and differential circadian patterns using repeated measurements, showing improved statistical power and validity.

This paper introduces CircaPower, a statistical method for power calculation in circadian rhythmicity detection, validated through simulations and real data.

This paper introduces likelihood-based methods to detect circadian rhythmicity and differential circadian patterns in transcriptomic data, showing improved error control and power in simulations and real data.

The paper profiles transcriptional diversity across skeletal, smooth, and cardiac muscles in mice and rats, revealing extensive gene expression differences and disease associations.