Jose Francisco Abisambra

This study shows that PERK deficiency worsens molecular, structural, and network damage in mice after repetitive mild traumatic brain injury.

This study shows that loss of normal Tau function in the adult brain causes neuronal atrophy, epigenetic changes, and cognitive/mood deficits, which can be reversed by Tau re-expression or epigenetic correction.

This study identifies a PERK-B/DLX1 pathway as a novel driver of tau pathology in human PSP and flies, showing DLX1 promotes tau toxicity.

This study identifies plasma proteomic signatures associated with repetitive head impact exposure and CTE, linking them to immune, mitochondrial, and metabolic pathways and cognitive decline.

This study examines how age affects brain connectivity and white matter integrity after repetitive mild traumatic brain injuries in mice using multimodal imaging techniques.

This study shows that targeted brain-specific tauopathy in mice leads to skeletal muscle weakness and altered gene expression.

The paper presents a method for simultaneous spatial analysis of metabolome, lipidome, and glycome from a single tissue section using mass spectrometry imaging and a computational framework called Sami.

This study investigates how repetitive mild traumatic brain injury (rmTBI) affects brain functional connectivity and protein profiles in mice, revealing altered connectivity and inflammatory responses.

The paper treats early-stage tau transgenic mice with a multi-target kinase inhibitor, showing cognitive improvement and proteomic shifts similar to Alzheimer's disease in humans.