Sadi Quiñones

This paper constructs a spatial metabolomic atlas of exercise in mice, identifies Complex I as a key target for reducing tau pathology, and shows that enhancing its activity mimics exercise's protective effects.

The paper maps spatial metabolome coherence across mouse brain regions using MALDI imaging and optimal transport, showing preserved coherence in Alzheimer's model despite metabolic changes and demonstrating intervention effects.

This study shows that a single closed-head mild traumatic brain injury (mTBI) in mice temporarily increases atypical astrocytes (AtAs) but they do not persist long-term, unlike in repeated mTBI.

This study uses snRNA-seq and spatial transcriptomics to create a pediatric and adult brain cell atlas, identifying cell type-specific gene expression changes during human brain maturation.

The paper shows that PV-INs have unique metabolic specializations lost after TBI, which can be rescued by 2-deoxyglucose, and identifies PGC-1α and lncRNAs as key factors in this dysfunction.

This study shows that traumatic brain injury disrupts functional connectivity in mice, with recovery and state-dependent changes in connectivity and theta power during stillness.