Author

Layne Pruitt

Houston MethodistORCID 0000-0001-8603-0881Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:phylogenetics / evolution· 1

Frequent Co-Authors

James M. MusseriD· 2 shared Matthew Ojeda SaavedraiD· 2 shared Prasanti Yerramilli· 2 shared Chia‐Wei ChouiD· 1 shared Christopher A. CottrelliD· 1 shared Daniel R. BoutziD· 1 shared David W. Bernard· 1 shared Ghazaleh EskandariiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersGenetics

James M. MusserORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintApr 18, 2025

Antigen avidity drives the durability of the vaccine immune response.

Nicole G. Weidner, Mauricio V. Padilla, Layne Pruitt…·Robert K. Abbott

This study shows that antigen avidity affects the durability and diversity of vaccine-induced immune responses by influencing germinal center dynamics and B cell outcomes.

4 citations

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

GeneticsmBioPeer-reviewedNov 2, 2020

Molecular Architecture of Early Dissemination and Evolution of the SARS-CoV-2 Virus in Metropolitan Houston, Texas

Scott Wesley Long, Randall J. Olsen, Paul A. Christensen…·James M. Musser

The paper sequences 320 SARS-CoV-2 genomes from Houston to study early pandemic spread, finding diverse origins and no evidence of more virulent strains.

146 citationstop 3%

viruswhole-genome sequencing

𝕏 PostBluesky

GenomicsJournal of Clinical MicrobiologyPeer-reviewedJun 9, 2020

Population genomic molecular epidemiological study of macrolide resistant Streptococcus pyogenes in Iceland,1995-2016: Identification of a large clonal population with a pbp2x mutation conferring reduced in vitro beta-lactam susceptibility

Sara B. Southon, Stephen B. Beres, Priyanka Kachroo…·Karl Gustaf Kristinsson

The paper analyzes whole genome sequencing data of macrolide-resistant Streptococcus pyogenes isolates in Iceland to identify clonal populations and resistance mechanisms.

41 citations

humanwhole-genome sequencing

𝕏 PostBluesky