Author

Kyle A. Beckman

Chan Zuckerberg Biohub San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Organism:human· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

Bo HuangiD· 2 shared Han LiiD· 2 shared Jonathan S. WeissmaniD· 2 shared Manuel D. LeonettiiD· 2 shared Veronica PessinoiD· 2 shared Aaron McGeeveriD· 1 shared Barbara PanningiD· 1 shared Cindy Tzu-Ling HuangiD· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Bo HuangORCID

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2 papers

Recent·Most cited

Design and specificity of long ssDNA donors for CRISPR-based knock-in

Han Li, Kyle A. Beckman, Veronica Pessino, Bo Huang, Jonathan S. Weissman, Manuel D. Leonetti

Long single-stranded DNA donors enable gene-sized CRISPR knock-in in human cells, though an author update notes subsequent long-read sequencing revealed high imprecise integration rates for both donor types.

bioRxiv · Nov 20, 2019 · PreprintMolecular Biology

Deep profiling reveals substantial heterogeneity of integration outcomes in CRISPR knock-in experiments

Hera Canaj, Jeffrey A. Hussmann, Han Li, Kyle A. Beckman, Leeanne Goodrich, Nathan H. Cho, Yucheng J. Li, Daniel A. Santos, Aaron McGeever, Edna M. Stewart, Veronica Pessino, Mohammad A. Mandegar, Cindy Tzu-Ling Huang, Li Gan, Barbara Panning, , Manuel D. Leonetti

Long-read sequencing with the knock-knock pipeline profiles CRISPR knock-in repair, finding perfect homology-directed repair is often a minority of integration events and mis-integration varies by context.

bioRxiv · Nov 13, 2019 · PreprintGenomics