Matthew Wooten

This study identifies aclarubicin's mechanism of action by showing it disrupts RNA polymerase II progression at replication-coupled histone genes, leading to chromatin damage.

This study develops Nascent CUT&Tag to measure transcription factor binding on nascent chromatin and finds that GAF recovers faster than PHO in Drosophila cells, with differences in motif length and functional associations.

The paper introduces CUT&TIME, a method to map historical chromatin accessibility in single cells during neurogenesis, revealing early changes in promoter accessibility linked to cell-fate commitment in retinal ganglion cells.

The paper shows that reduced levels of lagging strand polymerases in stem cells lead to asymmetric histone incorporation, which can be induced in progenitor cells through genetic or chemical manipulation.

This study shows aclarubicin increases RNA polymerase II elongation and alters chromatin accessibility and DNA structures in Drosophila cells.

The paper investigates pruriception and neuronal coding in nociceptor subtypes in humans and nonhuman primates, finding differences in pruritogen activation and responses compared to rodents.

This study shows that asymmetric histone inheritance in Drosophila male germline stem cells leads to differential chromosomal condensation and Cdc6 association, affecting cell cycle progression and fate decisions.

The paper shows that histone H4 is asymmetrically inherited in Drosophila male germline stem cells during asymmetric division, while H2A and H2B are symmetrically inherited.