Jonathan C. Snedeker

Reduced Levels of Lagging Strand Polymerases Shape Stem Cell Chromatin

The paper shows that reduced levels of lagging strand polymerases in stem cells lead to asymmetric histone incorporation, which can be induced in progenitor cells through genetic or chemical manipulation.

Roles of the distinct N-terminal amino acid between H3 and H3.3 in Drosophila male germline stem cell lineage

This study shows that the N-terminal amino acid difference between H3 and H3.3 in Drosophila male germline stem cells affects their inheritance patterns and function in stem cell maintenance and differentiation.

Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin

The paper uses single-molecule imaging to study chromatin remodelers in budding yeast, revealing their fast kinetics and ATP-dependent dissociation from chromatin.

Differential condensation of sister chromatids coordinates with Cdc6 to ensure distinct cell cycle progression in Drosophila male germline stem cell lineage

This study shows that asymmetric histone inheritance in Drosophila male germline stem cells leads to differential chromosomal condensation and Cdc6 association, affecting cell cycle progression and fate decisions.

Unidirectional fork movement coupled with strand-specific histone incorporation ensures asymmetric histone inheritance

The paper shows that histone H4 is asymmetrically inherited in Drosophila male germline stem cells during asymmetric division, while H2A and H2B are symmetrically inherited.

Stem cell mitotic drive ensures asymmetric epigenetic inheritance

The paper shows that stem cell mitotic drive ensures asymmetric sister chromatid attachment and segregation through epigenetic differences at sister centromeres.