Curtis J. Mello

Somatic DNA-repeat expansions initiate distinct yet analogous changes in Huntington's disease cortical and striatal neurons

This study shows that somatic DNA-repeat expansions in cortical and striatal neurons of Huntington's disease initiate similar pathological changes, but lead to distinct gene expression outcomes.

Sibling chimerism among microglia in marmosets

The paper identifies sibling-derived chimerism in microglia and macrophages across marmoset tissues using single-cell RNA-seq, showing hematopoietic origin and regional variation in brain microglia.

Common variation of cell abundances and gene expression in the human striatum

The paper analyzes single-nucleus RNA-seq data from the human striatum and prefrontal cortex to study inter-individual variation in cell abundances and gene expression, finding age-related changes and genetic associations.

Human genetic variation shapes the response of neurons to interferons

The paper identifies genetic variants that influence neuronal responses to interferons by analyzing gene expression and STAT1 binding in iPSC-derived neurons.

Efficient generation of lower induced Motor Neurons by coupling Ngn2 expression with developmental cues

This study combines Ngn2 overexpression with small molecule patterning to efficiently generate lower induced Motor Neurons (liMoNes) from hPSCs, achieving high yields and functional characteristics.

Natural variation in gene expression and Zika virus susceptibility revealed by villages of neural progenitor cells

The paper identifies a common genetic variant in IFITM3 that explains most inter-individual variation in neural progenitor cell susceptibility to Zika virus using natural genetic variation and synthetic perturbations.

Mapping genetic effects on cellular phenotypes with "cell villages"

Census-seq pools cells from >100 human donors into "cell villages" and quantifies donor DNA before and after selection to map genetic effects on cellular traits.

Insights about variation in meiosis from 31,228 human sperm genomes

The paper analyzes 31,228 human sperm genomes to study meiotic variation, finding differences in aneuploidy rates and crossover patterns across donors and gametes.