Karl Rössler

Nanoscale remodeling of synaptic glutamate receptors and calcium channels in temporal lobe epilepsy

This study examines nanoscale changes in synaptic proteins in human temporal lobe epilepsy, finding increased AMPA receptor density and altered calcium channel organization in specific synapse types.

Hippocampal CA3 forms a two-layer network of molecularly distinct cell types in mice and humans

The paper identifies two molecularly distinct subtypes of CA3 pyramidal neurons in mice and humans, revealing their unique anatomical and functional roles in hippocampal circuits.

Beyond the Resection: Surgical White Matter Disruption alters Non-Resected Brain Anatomy

This study investigates postoperative atrophy in non-resected brain regions following resective neurosurgery, linking it to transneuronal degeneration and showing that structural network reorganisations may be artifacts of image processing.

Human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory

This study identifies unique connectivity and synaptic rules in human hippocampal CA3 circuits that enhance associative memory capacity compared to rodents.

The genomic landscape across 474 surgically accessible epileptogenic human brain lesions

This study identifies somatic and germline genetic variants in 474 epileptogenic brain lesions, revealing associations with specific epilepsy subtypes and informing clinical genetic screening.

Uncovering brain tissue architecture across scales with super-resolution light microscopy

The paper introduces CATS, a method to map brain tissue architecture across scales, demonstrating its application to hippocampal mossy fiber circuitry.

A systematic characterization of intrinsically formed microglia-like cells during retinal organoid differentiation.

The paper identifies microglia-like cells forming in retinal organoids and characterizes their protein composition and localization.

Mosaic trisomy of chromosome 1q in human brain tissue associates with unilateral polymicrogyria, very early-onset focal epilepsy, and severe developmental delay

The paper identifies a chromosomal duplication of chromosome 1q in a subset of polymicrogyria patients, associated with specific clinical features and distinct DNA methylation patterns.