Juan Carlos Chara

This study shows that oligodendrocytes internalize exogenous myelin, enhancing their proliferation and differentiation through transcriptional changes and lipid droplet formation.

This study shows that MCT2 is essential for oligodendrocyte myelin maintenance and axonal support, and its loss leads to myelin and axonal damage, which can be mitigated by a ketogenic diet.

This study identifies TAF1-dependent transcriptional dysregulation as a mechanism underlying multiple sclerosis progression and presents an in vivo model for therapeutic development.

This study shows that genetically-modified macrophages can deliver Sema3F to demyelinating lesions, increasing OPC recruitment and accelerating remyelination in mice.

This study shows clemastine increases oligodendrocyte differentiation but impairs myelination during development, likely due to microglia-oligodendrocyte interactions.

This study shows baclofen, a GABABR agonist, promotes remyelination in mouse models of demyelination, suggesting it could be a therapeutic for multiple sclerosis.