Marı́a Domercq

Internalization of exogenous myelin by oligodendroglia promotes lineage progression

This study shows that oligodendrocytes internalize exogenous myelin, enhancing their proliferation and differentiation through transcriptional changes and lipid droplet formation.

Monocarboxylate transporter 2 is required for the maintenance of myelin and axonal integrity by oligodendrocytes

This study shows that MCT2 is essential for oligodendrocyte myelin maintenance and axonal support, and its loss leads to myelin and axonal damage, which can be mitigated by a ketogenic diet.

IRF5 regulates microglial myelin clearance and cholesterol metabolism after demyelination

This study shows that IRF5 regulates microglial myelin clearance and cholesterol metabolism after demyelination, with implications for remyelination in multiple sclerosis.

Microglial phagocytosis dysfunction during stroke is prevented by rapamycin

This study shows that microglial phagocytosis dysfunction during stroke is prevented by rapamycin, highlighting its potential as a therapeutic target.

Microglia and meningeal macrophages depletion delay the onset of experimental autoimmune encephalomyelitis

The paper shows that depleting microglia and meningeal macrophages delays the onset of EAE by reducing antigen presentation and T cell reactivation.

Clemastine induces an impairment in developmental myelination

This study shows clemastine increases oligodendrocyte differentiation but impairs myelination during development, likely due to microglia-oligodendrocyte interactions.