Author

H. Steven Seifert

Northwestern UniversityORCID 0000-0001-8651-0375Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Alain Oregioni· 1 shared Alexei V. SavchenkoiD· 1 shared Chris Lorenz· 1 shared Eliza Ploskon· 1 shared G. MinasoviD· 1 shared J. S. BrunzelleiD· 1 shared James GarnettiD· 1 shared Julia RosecransiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

Alain Oregioni

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintNov 9, 2026

Structural and functional examination of Neisseria gonorrhoeae TfpC reveals a dynamic two-domain architecture required for type IV pilus function

Kathleen R Nicholson, Maria Baczynska, Eliza Ploskon…·James Garnett

This study examines the structure and function of Neisseria gonorrhoeae TfpC, revealing its dynamic two-domain architecture essential for type IV pilus function.

DOI 10.64898/2026.11.06.764878

humanproteomics

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MicrobiologyProceedings of the National Academy of SciencesPeer-reviewedJun 23, 2026

Restriction-modification systems are required for Neisseria gonorrhoeae pilin antigenic variation

Selma Metaane, H. Steven Seifert

This study shows that restriction-modification systems in Neisseria gonorrhoeae are essential for pilin antigenic variation by cleaving specific sequences in pilin loci.

DOI 10.1073/pnas.2602688123

humanexperimental assay

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MicrobiologyProtein SciencePeer-reviewedFeb 19, 2025

Torsional Twist of the SARS-CoV and SARS-CoV-2 SUD-N and SUD-M domains

Mónica Rosas‐Lemus, G. Minasov, J. S. Brunzelle…·K.J.F. Satchell

The paper resolves the x-ray structure of SARS-CoV and SARS-CoV-2 SUD-N/M domains and shows they have rotational flexibility, with disulfide bonds absent in pangolin-SARS and related viruses.

2 citations

structural biologyexperimental assay

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