Abdul Rafeh Naqash

Telomere maintaining germline and somatic variants in thyroid cancer and melanoma

The paper examines the mutual exclusivity and clinical associations of germline long-telomere syndrome variants and somatic TERT promoter mutations in thyroid cancer and melanoma, finding they are mutually exclusive but have distinct clinical impacts.

Perturbational single-cell profiling of patient tumors defines lineage- and context-specific programs of innate immune resistance

The paper uses patient tumor samples to identify lineage- and context-specific mechanisms of innate immune resistance through perturbational single-cell RNA sequencing.

Tenascin-C in the early lung cancer tumor microenvironment promotes progression through integrin activation and FAK

This study shows that Tenascin-C promotes early lung cancer progression by activating integrins and FAK in mouse models and human lung adenocarcinomas.