Arash Latifkar

This study shows coronavirus infection limits PABPC1 activity, destabilizing short-tailed host mRNAs and enabling viral mRNAs to maintain specific poly(A)-tail lengths through synthesis and capping mechanisms.

The paper shows that during prolonged mitotic arrest, the transcriptome is stabilized through increased mRNA half-lives and reduced deadenylation, dependent on PABPC1 and PABPC4.