Fredrik Salmén

This study identifies WNT inhibition-dependent and -independent transcriptional regulators guiding human ventricular cardiomyocyte specification using single-cell RNA sequencing.

The paper develops T-ChIC to detect histone modifications and full-length transcripts in single cells, revealing sequential epigenetic changes during lineage commitment in gastruloids.

The paper introduces VASA-seq, a method for total single-cell RNA-seq in mice, revealing non-coding RNA expression and alternative splicing during development.

This paper introduces HDST, a high-resolution spatial transcriptomics method, and demonstrates its application in mouse brain tissue to resolve spatial expression patterns and cell types.

This study uses multidimensional transcriptomics to analyze immune cell distribution and identity in HER2+ breast tumors, revealing spatial heterogeneity and interpatient differences in immune infiltration.