Author
Hubrecht Institute for Developmental Biology and Stem Cell ResearchORCID 0000-0002-0444-128XUnclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
5 papers
Recent·Most cited
Marloes Blotenburg, Lianne C Suurenbroek, Vivek Bhardwaj, Peter J. Zeller
This study shows that optimizing mouse embryonic stem cell pluripotency state improves the consistency and complexity of gastruloid development.
Marloes Blotenburg, Vivek Bhardwaj, Buys de Barbanson…·Alexander van Oudenaarden
The paper develops T-ChIC to detect histone modifications and full-length transcripts in single cells, revealing sequential epigenetic changes during lineage commitment in gastruloids.
Vladyslav Bondarenko, Mikhail Nikolaev, Dimitri Kromm…·Takashi Hiiragi
This study develops an engineered uterus-like microenvironment to study mouse embryo implantation, revealing coordination between trophoblast migration and embryo growth.
Mélanie A. Eckersley-Maslin, Aled Parry, Marloes Blotenburg…·Wolf Reik
This study identifies Dppa2/4 as epigenetic factors that establish bivalency at developmental promoters, enabling lineage commitment by maintaining poised RNA polymerase and preventing DNA methylation.
Mélanie A. Eckersley-Maslin, Celia Alda-Catalinas, Marloes Blotenburg…·Wolf Reik
This study identifies Dppa2 and Dppa4 as upstream regulators of the Dux-driven zygotic transcriptional programme in 2C-like cells.