Author

Yudou He

UC San Diego Health SystemORCID 0000-0001-8733-8781Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Ludmil B. AlexandroviD· 2 shared Alvin Wei Tian NgiD· 1 shared Ammal AbbasiiD· 1 shared Andreas J GruberiD· 1 shared Annalise Katz‐SummercorniD· 1 shared Azhar KhandekariD· 1 shared Boian S. AlexandroviD· 1 shared Brian J. ReidiD· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioinformatics

Ludmil B. AlexandrovORCID

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2 papers

Recent·Most cited

BioinformaticsCell GenomicsPeer-reviewedSep 23, 2022

Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor

S. M. Ashiqul Islam, Marcos Díaz‐Gay, Yang Wu…·Ludmil B. Alexandrov

SigProfilerExtractor is a tool for de novo mutational signature extraction that outperforms existing methods and identifies four novel signatures, including one linked to tobacco smoking.

369 citationstop 1%

humanwhole-genome sequencing

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GenomicsbioRxivPreprintJul 25, 2022

Extrachromosomal DNA in the cancerous transformation of Barrett's esophagus

Jens Luebeck, Alvin Wei Tian Ng, Patricia C. Galipeau…·Paul S. Mischel

The paper investigates the development and evolution of extrachromosomal DNA (ecDNA) in Barrett's esophagus patients progressing to esophageal adenocarcinoma, finding ecDNA is strongly associated with cancer progression and enriched for oncogenes and immunomodulatory genes.

DOI 10.1101/2022.07.25.501144

humanwhole-genome sequencing

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