Extrachromosomal DNA in the cancerous transformation of Barrett's esophagus
Jens Luebeck, Alvin Wei Tian Ng, Patricia C. Galipeau, Xiaohong Li, Carissa A. Sanchez, Annalise Katz‐Summercorn, Hoon Kim, Sriganesh Jammula, Yudou He, Scott Michael Lippman, Roel G.W. Verhaak, Carlo C. Maley, Ludmil B. Alexandrov, Brian J. Reid, Rebecca Claire Fitzgerald, , Paul S. Mischel
The paper investigates the development and evolution of extrachromosomal DNA (ecDNA) in Barrett's esophagus patients progressing to esophageal adenocarcinoma, finding ecDNA is strongly associated with cancer progression and enriched for oncogenes and immunomodulatory genes.
bioRxiv · Jul 25, 2022 · PreprintGenomics