Jeffrey Louis Goldberg

Vis-OCT Explorer: an open-source software for visible-light optical coherence tomography data processing

Vis-OCT Explorer processes vis-OCT data to improve image quality and measurement repeatability for retinal analysis.

Deep learning-guided design of cell type-specific AAV promoters

This study designs cell type-specific AAV promoters using deep learning, outperforming rational approaches in mouse retinal cells and showing promise for human applications.

Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration

This study identifies OPTN's role in axonal mitochondria transport and shows its loss contributes to neurodegeneration in models of ALS and NTG.

The Cousa objective: a long working distance air objective for multiphoton imaging in vivo

The paper introduces a long working distance air objective for multiphoton imaging in vivo, demonstrating its performance across multiple species and imaging systems.

Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration

The paper identifies REST/NRSF as a suppressor of CNS axon regeneration using systems biology approaches and validates its role through genetic manipulations.

Dynamics of contrast decrement and increment responses in human visual cortex

The paper investigates contrast decrement and increment responses in human visual cortex using VEPs, finding differences in amplitude, latency, and spatial tuning that mirror findings in animal models.

Silicone oil-induced ocular hypertension in mouse models glaucomatous neurodegeneration and neuroprotection

This paper develops a reversible mouse model of secondary glaucoma using silicone oil and validates it for testing neuroprotective therapies.

Light-evoked activity and BDNF regulate mitochondrial dynamics and mitochondrial localized translation

The paper shows that light-evoked activity and BDNF regulate mitochondrial dynamics and localized translation in axons during retinal ganglion cell maturation.