Molecular BiologybioRxivPreprint
SMG6-dependent RNA decay maintains dsRNA homeostasis and restrains immunogenicity in hepatocellular carcinoma
Enes S. Arpa, Virginie Ricci, Ilja E. Shapiro…·David Gatfield
This study shows that SMG6-dependent NMD prevents dsRNA accumulation and immunogenicity in HCC by maintaining dsRNA homeostasis and suppressing MHC-I-presented peptides.
DOI 10.1101/2025.01.13.632668