SMG6-dependent RNA decay maintains dsRNA homeostasis and restrains immunogenicity in hepatocellular carcinoma
Enes S. Arpa, Virginie Ricci, Ilja E. Shapiro, Marija Jokic, Yahya Mohammadzadeh, Lisa Bertrand, Irene González-Menéndez, Leticia Quintanilla‐Martinez, Alexandre Pierre Benechet, Dirk Mossmann, Michael N. Hall, Jan Rehwinkel, Giovanni Ciriello, Tatiana V. Petrova, Sanjiv A. Luther, , David Gatfield
This study shows that SMG6-dependent NMD prevents dsRNA accumulation and immunogenicity in HCC by maintaining dsRNA homeostasis and suppressing MHC-I-presented peptides.
bioRxiv · Jan 13, 2025 · PreprintMolecular Biology