Enes S. Arpa

The paper investigates how SMG5 licenses SMG6 endonuclease activity in NMD by forming a composite active site with SMG6 PIN domain.

This study shows that SMG6-dependent NMD prevents dsRNA accumulation and immunogenicity in HCC by maintaining dsRNA homeostasis and suppressing MHC-I-presented peptides.

The paper investigates diurnal regulation of IRE-containing mRNAs via IRP1 and IRP2 in mouse liver, showing that feeding rhythms drive rhythmicity even without a functional circadian clock.

This study uses a Smg6 mouse model to show that NMD pathway downregulation affects circadian period length and daily CRY2 mRNA accumulation.