Stefano L. Giandomenico

The paper shows that mouse neural organoids can replicate the synaptic proteome of mature brains through optimized protocols and proteomics analysis.

This study identifies POMP as a stress-induced transcriptional regulator that buffers proteasome dysfunction through a non-canonical role in nucleolar RNA processing.

The paper identifies synapse type-enriched proteins and their functional associations across brain regions and cell types using proteomic analysis.

The paper identifies a proteasomal 19S subcomplex that regulates neuronal synapses independently of the 20S catalytic subunit through deubiquitylation of Lys63-ubiquitin.

This study shows that cerebral organoids cultured at the air-liquid interface form functional nerve tracts with diverse morphologies and connectivity.