Georgi Tushev

Localized mRNAs and protein synthesis in cortical layer 1

The paper identifies localized mRNAs and proteins in cortical layer 1 synapses, showing specialized transcriptomes and suggesting local translation supports layer-specific functions.

Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology

The paper investigates how ischemic injury affects microglial response to Aβ pathology, finding a protective microglial phenotype that promotes benign Aβ plaque formation.

Chromosome-scale genome assembly of the European common cuttlefish Sepia officinalis

The paper presents a chromosome-scale genome assembly of the common cuttlefish Sepia officinalis, revealing its true karyotype and identifying cephalopod-specific gene expansions.

Direct interaction of ribosomes with postsynaptic proteins gives rise to a privileged local synaptic translatome

The paper identifies a direct interaction between postsynaptic proteins and ribosomes, revealing a localized synaptic translatome that preferentially translates PSD-related mRNAs.

Brain-wide synaptosome profiling reveals localized mRNAs that diversify synapses

The paper profiles synaptic transcriptomes across five brain regions in mice, identifying mRNAs enriched at synapses and their role in synaptic diversity and function.

The molecular diversity of hippocampal regions and strata at synaptic resolution revealed by integrated transcriptomic and proteomic profiling

The paper integrates transcriptomic and proteomic data from mouse hippocampal regions and synapses to reveal molecular diversity and co-regulation patterns.

Neuronal processes contain the essential components for the late steps of ribosome biogenesis

The paper shows that ribosome biogenesis factors and pre-rRNA processing enzymes are present in distal neuronal compartments, suggesting local ribosome maturation occurs in dendrites.

The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator

This study identifies POMP as a stress-induced transcriptional regulator that buffers proteasome dysfunction through a non-canonical role in nucleolar RNA processing.

The proteomic landscape of synaptic diversity across brain regions and cell types

The paper identifies synapse type-enriched proteins and their functional associations across brain regions and cell types using proteomic analysis.

Subcellular sequencing of single neurons reveals the dendritic transcriptome of GABAergic interneurons

The paper develops a method to profile subcellular transcriptomes of single neurons, revealing that GABAergic interneurons have localized mRNAs similar to excitatory neurons.

The mRNA translation landscape in the synaptic neuropil.

The paper identifies and quantifies the transcriptome and translatome in neuronal cell bodies, dendrites, and axons using RNA-seq and Ribo-seq, revealing that local translation is a major source of synaptic proteins.

Monosomes actively translate synaptic mRNAs in neuronal processes

The paper shows that monosomes, not polysomes, are the main sites of active translation for synaptic mRNAs in neuronal processes, contributing to local protein synthesis.

Poly(A) Binding Protein Nuclear 1 regulates the polyadenylation of key synaptic plasticity genes and plays a role in homeostatic plasticity

This study shows that Pabpn1 regulates polyadenylation of synaptic plasticity genes and affects homeostatic plasticity in neurons.