Lawrence Charles Smith

This study evaluates a multi-target small-molecule cocktail, GUSTC, to reduce repressive heterochromatin marks in bovine fibroblasts, enhancing reprogramming potential without improving embryo development.

This study validates a single oocyte biopsy method in bovine by comparing it to whole oocytes, showing high correlation in gene expression despite minor differences.

This paper predicts oocyte competence in bovine using RNA-seq and WGBS from biopsies, cumulus cells, granulosa cells, and polar bodies, identifying transcriptional and epigenetic differences between cleaved but arrested and blastocyst-stage embryos.

This study identifies imbalanced WNT signaling and altered pluripotency markers in bovine haploid androgenetic embryos, showing that WNT pathway modulation can improve blastocyst formation.

The paper investigates the effects of beta-hydroxybutyrate on histone lysine beta-hydroxybutyrylation and transcriptome changes in bovine fibroblasts and cumulus-oocyte complexes, showing altered gene expression but no impact on oocyte meiotic competence.

This study investigates the developmental issues in bovine haploid androgenetic embryos, identifying epigenetic dysregulation of imprinted and X-linked genes as a key factor.

This study inhibits EHMT1/2 with UNC0638 in bovine cells during reprogramming, reducing H3K9me2 and other marks but not improving preimplantation development.