Jacinthe Therrien

Assessment of Total Oocyte Transcripts Representation through Single Ooplasm Biopsy in Bovine with High Reliability

This study validates a single oocyte biopsy method in bovine by comparing it to whole oocytes, showing high correlation in gene expression despite minor differences.

Retrospective model utilizing biopsies, granulosa cells, and polar body to predict oocyte competence in bovine

This paper predicts oocyte competence in bovine using RNA-seq and WGBS from biopsies, cumulus cells, granulosa cells, and polar bodies, identifying transcriptional and epigenetic differences between cleaved but arrested and blastocyst-stage embryos.

Haploid androgenetic development in bovines reveals imbalanced WNT signaling and impaired cell fate differentiation.

This study identifies imbalanced WNT signaling and altered pluripotency markers in bovine haploid androgenetic embryos, showing that WNT pathway modulation can improve blastocyst formation.

Dysregulated gene expression of imprinted and X-linked genes: a link to poor development of bovine haploid androgenetic embryos

This study investigates the developmental issues in bovine haploid androgenetic embryos, identifying epigenetic dysregulation of imprinted and X-linked genes as a key factor.