Qi Li

This study develops a multiscale cytoskeletal network model to simulate shear rheological properties and their evolutionary mechanisms, revealing how chemo-mechanical coupling and actin filament dynamics influence cellular mechanical responses.

This paper identifies ISM1 as a key regulator of iPSC-CM maturation through p53 activation, improving structural and metabolic features.

The paper uses controlled microtrauma combined with molecular cues to promote regenerative skin repair with appendages in animal models.

This study shows that NF1 deficiency in glioblastoma promotes metabolic reprogramming and epithelial-mesenchymal transition through AKT/mTOR activation and MFN1 regulation.

This study evaluates leritrelvir's effectiveness against Mpro variants with resistance mutations, showing it restores dimerization and maintains inhibitory activity better than nirmatrelvir.

inGSEA improves gene set enrichment analysis by using a weighted integral statistic, enhancing detection power and reducing computational burden.

The paper shows that nuclear N-glycans modify INM proteins, regulate H3K9me3, and maintain genomic stability by interacting with SETDB1.