P. R. Hof

Transcriptomic changes across subregions of the primate cerebellum support the evolution of uniquely human behaviors

The paper analyzes bulk RNA-seq data from six primate cerebellar subregions to identify gene expression differences across species, highlighting divergence in synaptic activity and glucose metabolism in lateral hemispheres.

Integrated platform for multi-scale molecular imaging and phenotyping of the human brain

The paper develops a platform for multi-scale molecular imaging and phenotyping of the human brain, integrating novel tools for tissue processing, imaging, and computational reconstruction.

Tempo and mode of gene expression evolution in the brain across Primates

The paper analyzes RNA-Seq data from 18 primate species to study gene expression evolution in the brain, identifying genes correlated with brain size and under positive selection.

Evolution of regulatory signatures in primate cortical neurons at cell type resolution

This study identifies cell-type-specific regulatory changes in human, chimpanzee, and rhesus macaque cortical neurons, revealing human-specific regulatory elements linked to language and psychiatric disorders.

Repeated hypoglycemia blunts the responsiveness of glucose-inhibited GHRH neurons by remodeling neural inputs and disrupting mitochondrial structure and function.

This study shows repeated hypoglycemia reduces GHRH neuron responsiveness by altering neural inputs and mitochondrial function, suggesting mitochondrial dynamics as a target for preventing hypoglycemia unawareness.