Andrés E. Chávez

This study evaluates executive function impairments in EAAT3 overexpressing mice, finding deficits in cognitive flexibility, working memory, and impulsivity, while attention and motivation remain unaffected.

This study shows that overexpression of EAAT3 in hippocampal principal neurons impairs LTD and reversal learning, suggesting EAAT3 regulates synaptic plasticity and cognitive flexibility.

This study shows that deleting VPS50 in mice brains impairs synaptic function and behavior by disrupting V-ATPase pump localization and vesicle acidification.

This study identifies adenosine/A2A receptor retrograde signaling as a mechanism for presynaptic long-term potentiation and seizure promotion in hippocampal circuits.

This study shows that somatostatin neurons in the basal forebrain regulate cortical activity and behavior by modulating synaptic output.