David W. Gohara

This paper shows SARS-CoV-2 can tolerate reduced proofreading activity but requires a minimal ExoN activity threshold for viability, leading to a mutator phenotype and reduced replication efficiency.

This study characterizes the kinetic mechanism and structural dynamics of Chikungunya virus nsP2 RNA helicase during nucleotide hydrolysis using biochemical and computational methods.

This study identifies a fold switch in ONNV nsP4 that regulates its conformation, RNA binding, and polymerase activity through proteolytic cleavage and fold switching.