Abha Jain

This study identifies a fold switch in ONNV nsP4 that regulates its conformation, RNA binding, and polymerase activity through proteolytic cleavage and fold switching.

This study identifies a minimal functional precursor of CHIKV nsP4 required for RNA synthesis and shows cleavage by nsP2 protease is essential for replication.

This study shows that arabinose nucleotides inhibit SARS-CoV-2 and poliovirus polymerases by causing long pauses due to the 2'-endo conformation of the incorporated nucleotides.

This paper investigates how enteroviral RNA-dependent RNA polymerases perform forced-copy-choice RNA recombination, showing the role of a plus-one intermediate and preference for CMP over other nucleotides.