Yan Xiang

Structural Mechanisms of SAMD9 Autoinhibition and Pathogenic Dysregulation

This study determines the structural basis of SAMD9 autoinhibition and explains how pathogenic mutations disrupt this mechanism to cause disease.

Scarless SARS-CoV-2 Genome Engineering and Variant Analysis

This paper develops a scarless genome engineering system for SARS-CoV-2 to study protease inhibitors and drug resistance mechanisms, showing improved antiviral potency when combined with drug efflux inhibitors.

Recovery of proofreading-impaired SARS-CoV-2 reveals a mutator phenotype and an ExoN activity threshold for viability

This paper shows SARS-CoV-2 can tolerate reduced proofreading activity but requires a minimal ExoN activity threshold for viability, leading to a mutator phenotype and reduced replication efficiency.

Selective targeting of type II tRNAs underlies SLFN14-mediated translational repression and its dysregulation by thrombocytopenia-linked mutations

This study identifies SLFN14 as a ribosome-associated endoribonuclease that represses translation by selectively cleaving type II tRNAs, and shows how mutations linked to thrombocytopenia disrupt this mechanism.

Structural and Functional Studies of Rabbit SAMD9 Reveal a Distinct tRNase Module That Underlies the Antiviral Activity

This study identifies a distinct tRNase module in rabbit SAMD9 that retains antiviral activity despite structural differences from human SAMD9.